Researchers discover FOXO1 protein improves CAR T cell survival and function for cancer treatments.

Researchers from CHOP and Stanford Medicine found that FOXO1, a protein, improves CAR T cells' survival and function, potentially leading to more effective therapies for difficult-to-treat cancers. The protein activates genes linked to T cell memory, allowing CAR T cells to persist and fight cancer more effectively. This discovery may aid in improving CAR T cell therapy design and benefiting a wider range of patients.