Scientists discover compound that could boost CAR T cell therapy by targeting a protein in cancer cells.

Scientists at City of Hope have found that a protein called YTHDF2 helps cancer cells avoid CAR T cell therapy, a treatment for blood cancers. They discovered a new compound, CCI-38, which targets YTHDF2 and reduces cancer growth, potentially enhancing CAR T cell therapy's effectiveness. The next steps include improving CCI-38's safety and conducting clinical trials to develop more personalized cancer treatments.

3 months ago
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