University of Otago researchers discover a new regulatory mechanism in phage proteins interacting with bacteria's CRISPR-Cas system.
Researchers from the University of Otago have uncovered a new regulatory mechanism in proteins used by phages, viruses that infect bacteria. This mechanism, discovered by Professor Peter Fineran's team, sheds light on how phages interact with bacteria's CRISPR-Cas immune system. The HTH domain of the protein, previously thought to only bind DNA, can now also bind its RNA transcript, potentially leading to new alternatives to antibiotics and a deeper understanding of gene regulation.
July 10, 2024
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