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Wistar Institute researchers, led by Dr. Veglia, discovered how glioblastoma suppresses immune system via glucose-driven histone lactylation.
Wistar Institute researchers, led by Dr. Filippo Veglia, discovered a key mechanism by which glioblastoma, a deadly brain cancer, suppresses the immune system.
Their findings, published in Immunity journal, reveal how glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma.
Dr. Veglia believes that understanding these mechanisms could help develop effective treatments against this cancer.
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Los investigadores del Instituto Wistar, dirigidos por el Dr. Veglia, descubrieron cómo el glioblastoma suprime el sistema inmunológico mediante la lactilación de histonas impulsada por la glucosa.