Researchers found that cancer-produced protein PNMA2, resembling a virus, triggers immune response in the brain, causing memory loss and cognitive impairment.
Researchers at the University of Utah Health have discovered that some cancers can produce a protein that resembles a virus, triggering an out-of-control immune response that may harm brain cells. This discovery explains the rapid-onset memory loss and cognitive impairment observed in anti-Ma2 paraneoplastic neurological syndrome, a rare but serious complication of cancer in which the body's immune system attacks the brain. This protein, called PNMA2, assembles into a virus-like structure that initiates an immune reaction, potentially causing brain cell damage. The study, published in Cell, provides new insights that might help direct future treatment strategies.
Articles
Further Reading
You have 14 free stories remaining this month. Subscribe anytime for unlimited access.