Researchers identify key mechanisms of inflammation involving protein GSDMD, potentially leading to treatments for sepsis and autoinflammatory diseases.

Researchers at the University Hospital Bonn and the University of Bonn have uncovered key mechanisms of inflammation involving the protein gasdermin D (GSDMD), which forms pores in cell membranes, facilitating inflammatory responses and cell death. Utilizing nanobodies, they found these fragments can inhibit pore formation, potentially leading to treatments for conditions like sepsis and autoinflammatory diseases. Their findings are detailed in "Nature Communications."

September 26, 2024
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