Engineered NK cells expressing IL-21 combat glioblastoma stem cells, potentially leading to a new therapeutic approach.

Researchers at the University of Texas MD Anderson Cancer Center discovered that natural killer (NK) cells, engineered to express interleukin-21 (IL-21), effectively combat glioblastoma stem cell-like cells both in vitro and in vivo. Their findings could lead to a new therapeutic approach for the aggressive brain cancer, which has limited treatment options and poor survival rates. A clinical trial is anticipated to begin later this year for the application of IL-21 engineered NK cells in glioblastoma patients.

August 12, 2024
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