Study in Nature Chemical Biology identifies dual-action antibiotic macrolones with reduced resistance potential.

A study in Nature Chemical Biology reveals promising new antibiotics, called macrolones, are harder for bacteria to develop resistance against. Macrolones combine macrolides and fluoroquinolones, targeting bacteria in two ways, making it difficult for bacteria to evolve resistance simultaneously. This dual-action feature requires bacteria to change at least two genes, which is a significant hurdle. However, macrolones may not entirely eliminate resistance issues in the long term and the development of new antibiotics, careful use of existing ones, and exploring alternative antimicrobial materials remain vital for combating antimicrobial resistance.

August 02, 2024
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