Northwestern Medicine scientists used ultrasound and microbubbles to penetrate the blood-brain barrier, delivering a chemotherapy-immunotherapy cocktail to treat glioblastoma in four human patients and mouse models.
Northwestern Medicine scientists demonstrated a new therapy using ultrasound technology to penetrate the blood-brain barrier and aid delivery of a chemotherapy-immunotherapy cocktail to treat glioblastoma. The treatment, involving low-intensity pulsed ultrasound (LIPU) and microbubbles, allowed increased concentrations of liposomal doxorubicin and anti-PD-1 immunotherapy to enter the brain. The study showed success in four human patients and mouse models of glioblastoma.
June 06, 2024
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