US scientists discovered that fibroblast cell-produced collagen and proteins cause scarring in the eye, hindering anti-VEGF AMD treatments; targeting adenosine receptor 2A may improve efficiency.
US scientists from the Medical College of Georgia discovered that collagen and proteins produced by fibroblast cells cause fibrosis or scarring in the eye, blocking the effectiveness of anti-VEGF treatments for neovascular age-related macular degeneration (AMD). The study found that excessive endothelial cells produce fibroblast cells, and targeted the adenosine receptor 2A (Adora2a) to prevent fibrosis. The researchers are developing an antibody to block the activation of adenosine to Adora2A, which may improve the efficiency of current AMD treatments.
May 02, 2024
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