Scripps Research scientists found that LY2444296, a compound blocking kappa opioid receptors, reduced alcohol consumption in dependent animals, potentially informing new treatment options for alcohol use disorder.

Scripps Research scientists discovered that LY2444296, a compound that blocks the kappa opioid receptor (KOP), may reduce alcohol consumption in cases of dependence in animal studies. The findings, published in Scientific Reports, suggest that targeting and blocking the KOP system could potentially stop alcohol abuse and inform new treatment options for alcohol use disorder.

March 29, 2024
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