Springfield, MO hosts Route 66's 100th anniversary kickoff April 30 to May 2.

Springfield, Missouri, will mark the 100th anniversary of Route 66 in 2026 as the highway's birthplace. The city plans a three-day kickoff from April 30 to May 2 featuring a dedication ceremony, a national NBC broadcast, and a concert with Little Big Town and Chris Janson. Visitors can explore the Route 66 Museum and historic sites like the Gillioz Theatre, while also enjoying attractions such as Bass Pro Shops and a local zoo.