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Chinese scientists created a non-genetic CAR-T platform, FACE, that reduces leukemia relapse by enhancing cell interaction via CD71, using FDA-approved materials and showing promise in resistant cases.
Chinese scientists have developed a new CAR-T therapy platform called FACE that reduces leukemia relapse by enhancing cell-to-cell interaction using the CD71 protein, without genetic engineering.
The biomimetic system boosts CAR-T potency, enabling effective treatment with one-fifth the cell dose in mice and targeting chemotherapy directly to cancer cells.
It’s compatible with current manufacturing, uses FDA-approved materials, and shows promise across multiple leukemia types and resistant cases.
Experts highlight its potential to improve CAR-T therapy broadly.
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Los científicos chinos crearon una plataforma CAR-T no genética, FACE, que reduce la recaída de la leucemia al mejorar la interacción celular a través de CD71, utilizando materiales aprobados por la FDA y que se muestra prometedora en casos resistentes.