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Maternal antibodies protect most newborns from severe E. coli, but low levels increase risk, prompting research into probiotics and screening.
A new international study finds that maternal antibodies passed to newborns during pregnancy strongly protect against severe E. coli infections, explaining why such cases are rare—about 1 in 1,000 births.
Infants who develop sepsis have significantly lower levels of these antibodies, which target a key E. coli surface protein.
Researchers linked low antibody transfer to higher infection risk and found that a probiotic strain, Nissle 1917, can boost maternal antibody production in mouse models.
The findings suggest potential future screening for at-risk babies and probiotic or antibody-based interventions during pregnancy to enhance newborn protection.
Los anticuerpos maternos protegen a la mayoría de los recién nacidos de E. coli grave, pero los niveles bajos aumentan el riesgo, lo que impulsa la investigación sobre probióticos y pruebas de detección.