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GLP-1 drugs like Ozempic may reduce heart damage after heart attacks by improving blood flow in tiny vessels, UK study finds.
GLP-1 weight-loss drugs like Ozempic and Wegovy may help reduce heart damage after a heart attack by preventing "no-reflow," a condition where tiny heart blood vessels stay blocked despite clearing the main artery, according to a UK study.
In mouse models, the drugs relaxed pericytes—cells that constrict vessels during oxygen loss—by activating potassium channels, improving blood flow to damaged tissue.
The findings, published in Nature Communications, suggest these drugs could be repurposed to improve recovery, possibly even administered by paramedics during emergencies.
While prior research showed GLP-1 drugs lower cardiovascular risk independently of weight loss, this study offers a potential mechanism: enhanced microvascular blood flow.
Human trials are needed to confirm benefits and determine best use.
Los medicamentos GLP-1 como Ozempic pueden reducir el daño cardíaco después de los ataques cardíacos al mejorar el flujo sanguíneo en pequeños vasos, según un estudio del Reino Unido.