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Day One Biopharma beat Q4 revenue estimates but missed profit forecasts, with 2026 guidance reaffirmed and Mersana deal eyed as growth catalyst.
Day One Biopharmaceuticals reported Q4 2025 revenue of $53.72 million, exceeding estimates, with a net loss of $0.21 per share, missing expectations.
Full-year net product revenue reached $155.4 million, and the company reaffirmed 2026 U.S. net product revenue guidance of $225–$250 million.
The Mersana acquisition, adding Emi-Le to its pipeline, is seen as a key growth driver.
Analysts offered mixed ratings, with Wedbush upgrading to “outperform” and a $30 target, while others adjusted targets up or down.
The stock opened at $12.02 with a market cap of $1.23 billion, negative P/E, and insider sales reported.
The company continues to face profitability challenges despite top-line growth.
Day One Biopharma superó las estimaciones de ingresos del cuarto trimestre, pero no alcanzó las previsiones de ganancias, con la orientación de 2026 reafirmada y el acuerdo de Mersana considerado como un catalizador de crecimiento.