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Women experience longer pain after injury due to biological differences in immune cells, a study finds.
A new study in Science Immunology finds women experience longer-lasting chronic pain than men due to biological differences in immune cells called monocytes, which produce anti-inflammatory IL-10 to reduce pain.
These cells are less active in women, likely due to lower levels of sex hormones like testosterone, leading to slower pain resolution.
The research, led by Michigan State University, challenges the long-standing misconception that women’s pain is psychological, offering a biological basis for sex-based pain disparities.
Findings from human and mouse studies show men recover faster from injury-related pain, with higher IL-10 production.
Experts say the results could lead to new, non-opioid treatments targeting monocytes or topical testosterone, helping reduce reliance on painkillers and improve equitable care.
The study highlights historical biases in medical research that excluded women, contributing to gaps in understanding women’s health.
Las mujeres experimentan dolor más prolongado después de una lesión debido a las diferencias biológicas en las células inmunes, según un estudio.