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flag St. Jude's CEO James Downing will step down in late 2026 after 12 years, transitioning to a faculty role as a search for his successor begins.

flag St. Jude Children's Research Hospital announced that President and CEO James R. Downing will step down in late 2026 after a 12-year tenure, marking a planned leadership transition. flag Downing, who helped establish the Department of Pediatric Global Medicine in 2018, will transition to a faculty role. flag His leadership saw significant growth in research, clinical programs, and global outreach, including advancements in pediatric cancer genomics and major campus expansions. flag A global search for his successor is underway, with a new CEO expected to be named this summer and the handover completed by year’s end.

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