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High-altitude living may lower diabetes risk by boosting red blood cells' glucose absorption, a process mimicked by a promising new drug in mice.
People living at higher altitudes may have a lower risk of diabetes, with a new study finding that red blood cells act as glucose sinks in low-oxygen conditions, absorbing more sugar to help deliver oxygen to tissues.
Researchers discovered that under hypoxia, red blood cells increase glucose uptake via GLUT1 transporters programmed in the bone marrow, converting glucose into 2,3-DPG to enhance oxygen release.
This process lowers blood sugar, even without insulin.
A drug called HypoxyStat, which mimics high-altitude conditions, reversed high blood sugar in diabetic mice more effectively than some current treatments, offering a promising new approach to diabetes therapy.
Vivir a gran altitud puede reducir el riesgo de diabetes al aumentar la absorción de glucosa por los glóbulos rojos, un proceso imitado por un prometedor nuevo medicamento en ratones.