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Cats and humans share key cancer genes, with study revealing similar tumor mutations and treatment responses, advancing precision medicine for both.
A large-scale study of nearly 500 cats across five countries has found strong genetic similarities between feline and human cancers, particularly in genes like TP53, FBXW7, and PIK3CA, which are linked to aggressive breast and other cancers in humans.
Researchers identified shared mutations in 13 tumor types, including mammary, blood, and skin cancers, with feline tumors mirroring human patterns in both genetics and treatment response.
The findings, part of the "One Medicine" approach, suggest cats—due to shared environments and spontaneous tumor development—offer valuable insights for developing targeted therapies, with certain chemotherapy drugs showing better results in tumors with specific mutations.
The study, which created a publicly available database, marks a major step toward advancing precision medicine for both species.
Los gatos y los humanos comparten genes clave del cáncer, con un estudio que revela mutaciones tumorales similares y respuestas al tratamiento, lo que hace avanzar la medicina de precisión para ambos.