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A 2026 study found AMD3100, an approved drug, helps immune cells attack rare liver cancer by reversing their exclusion from tumors.
A February 17, 2026, study in Gastroenterology reveals that AMD3100, an FDA-approved drug, may overcome immunotherapy resistance in fibrolamellar carcinoma, a rare liver cancer affecting young people.
The research found tumor microenvironments trap immune T cells in fibrous regions, preventing cancer attack.
AMD3100 reversed this T-cell exclusion, enabling T cells to reach tumors.
Combined with immune checkpoint inhibitors, it significantly increased tumor cell death in patient samples.
Because AMD3100 is already approved, clinical trials for this cancer could begin quickly.
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Un estudio de 2026 encontró que AMD3100, un fármaco aprobado, ayuda a las células inmunes a atacar el cáncer de hígado raro al revertir su exclusión de los tumores.