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flag Scientists discover a brain circuit in mice that boosts exercise endurance, suggesting similar pathways may exist in humans.

flag Scientists at the University of Pennsylvania have found that a specific brain circuit in mice, involving SF1 neurons in the ventromedial hypothalamus, is critical for building endurance through exercise. flag These neurons become more active and form more connections after regular training, with blocked neurons preventing endurance gains and artificially activated ones improving performance. flag The brain's role in regulating energy use and metabolic adaptation challenges the idea that exercise benefits are purely physical. flag While the study was done in mice, researchers believe similar mechanisms may exist in humans, potentially offering new ways to enhance fitness, especially for older adults or those with mobility issues. flag The findings were published in Neuron on February 12, 2026.

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