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flag Nitazenes, ultra-potent synthetic opioids, caused over 280 overdose deaths in the UK by 2025, mostly among homeless men with mental health issues, with naloxone rarely available.

flag Nitazenes, synthetic opioids up to 100 times stronger than heroin, have caused hundreds of accidental overdose deaths in the UK since 2021, with 286 inquests by March 2025 linking the drug to fatalities. flag Often mixed into other drugs without users’ knowledge, they are particularly dangerous due to their potency and difficulty in detection. flag Most victims were men in their 40s with unstable housing and mental health challenges. flag Deaths mostly occurred at home, and naloxone—critical for reversing overdoses—was available in only 14% of cases. flag The UK’s death toll far exceeds that of other nations, highlighting a growing public health crisis.

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