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Food shortages reprogram immunity in mice, boosting fast-acting cells and saving energy, a study shows.
Food shortages trigger a metabolic reprogramming of the immune system via glucocorticoids, stress hormones that shift defense from energy-intensive T cells to faster-acting neutrophils, preserving memory T cells for long-term immunity.
This adaptation, observed in mice during calorie restriction, helps conserve energy while maintaining infection resistance by relocating immune cells to the bone marrow.
The findings, based on a study published February 10, 2026, suggest the immune system dynamically adjusts to nutrient scarcity and other stressors, with implications for managing infections and malnutrition in vulnerable populations.
La escasez de alimentos reprograma la inmunidad de los ratones, estimulando las células de acción rápida y ahorrando energía, según un estudio.