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IIT Bombay researchers created a gentler method to harvest lab-grown T-cells using biodegradable scaffolds, improving survival and function for cancer immunotherapy.
Researchers at IIT Bombay have developed a gentler method to recover lab-grown T-cells for cancer immunotherapies using polycaprolactone scaffolds that mimic the body’s natural environment.
Compared to traditional trypsin treatment, which damages cells, using the milder enzyme accutase significantly improved cell survival, preserved surface proteins, and maintained the cells’ ability to cluster and grow.
The technique, published in Biomaterials Science, could enhance the effectiveness and scalability of CAR T-cell therapies, potentially making advanced treatments more accessible.
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Los investigadores del IIT de Bombay crearon un método más suave para recolectar células T cultivadas en laboratorio utilizando andamios biodegradables, mejorando la supervivencia y la función para la inmunoterapia contra el cáncer.