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flag Pfizer's experimental monthly weight-loss drug showed up to 12.3% weight loss in trials, with mild side effects and no plateau, but shares dropped due to a 10% discontinuation rate.

flag Pfizer's experimental monthly GLP-1 drug, PF-3944, achieved up to 12.3% weight loss over 28 weeks in a mid-stage trial, with no plateau in results and generally mild side effects, according to data released on February 3, 2026. flag The drug, acquired through a $10 billion purchase of Metsera, is part of Pfizer’s push into the $150 billion obesity market, with plans for 10 Phase 3 trials in 2026 and potential approval by 2028. flag Despite strong fourth-quarter earnings and robust sales, Pfizer’s shares fell 3.5% amid concerns over a 10% discontinuation rate due to side effects, though no severe gastrointestinal events were reported. flag The company reaffirmed its 2026 revenue forecast despite patent expirations and pricing pressures.

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