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Pfizer's experimental monthly weight-loss drug showed up to 12.3% weight loss in trials, with mild side effects and no plateau, but shares dropped due to a 10% discontinuation rate.
Pfizer's experimental monthly GLP-1 drug, PF-3944, achieved up to 12.3% weight loss over 28 weeks in a mid-stage trial, with no plateau in results and generally mild side effects, according to data released on February 3, 2026.
The drug, acquired through a $10 billion purchase of Metsera, is part of Pfizer’s push into the $150 billion obesity market, with plans for 10 Phase 3 trials in 2026 and potential approval by 2028.
Despite strong fourth-quarter earnings and robust sales, Pfizer’s shares fell 3.5% amid concerns over a 10% discontinuation rate due to side effects, though no severe gastrointestinal events were reported.
The company reaffirmed its 2026 revenue forecast despite patent expirations and pricing pressures.
El medicamento experimental de pérdida de peso mensual de Pfizer mostró hasta un 12,3% de pérdida de peso en los ensayos, con efectos secundarios leves y ninguna meseta, pero las acciones cayeron debido a una tasa de interrupción del 10%.