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Australian researchers link high glucose uptake in lung cancer cells to immunotherapy resistance, using machine learning to identify metabolic patterns that could personalize treatment.
Australian scientists have found that lung cancer cells' glucose metabolism can predict immunotherapy response, with higher glucose uptake linked to treatment resistance.
Using machine learning, researchers at the University of Queensland analyzed non-small cell lung carcinoma tumors and identified metabolic "neighborhoods" influencing outcomes.
The discovery may help personalize treatment, improve immunotherapy effectiveness, and guide future therapies, with plans to expand the approach to other cancers.
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Los investigadores australianos vinculan la alta absorción de glucosa en las células de cáncer de pulmón a la resistencia a la inmunoterapia, utilizando el aprendizaje automático para identificar patrones metabólicos que podrían personalizar el tratamiento.