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A new antibody targeting a fat cell protein shows promise in treating a hard-to-treat liver cancer, according to Hong Kong researchers.
Researchers at The Hong Kong Polytechnic University, led by Prof. Terence Lee, have developed a monoclonal antibody that targets FABP4, a fat cell protein linked to metabolic dysfunction-associated steatotic liver disease (MASLD) and associated liver cancer.
The antibody neutralizes FABP4, reducing tumor growth and boosting immune response, offering a potential new treatment for a form of liver cancer resistant to current immunotherapies.
The findings, published in the Journal of Clinical Investigation, are supported by Hong Kong’s Innovation and Technology Fund, with a patent filed and further development underway.
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Según los investigadores de Hong Kong, un nuevo anticuerpo dirigido a una proteína de las células grasas se muestra prometedor en el tratamiento de un cáncer de hígado difícil de tratar.