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Oregon State researchers created an iron-based nanomaterial that kills breast cancer in mice using dual reactive oxygen species, with no toxicity or recurrence.
Researchers at Oregon State University have developed an iron-based nanomaterial that kills cancer cells by generating both hydroxyl radicals and singlet oxygen within tumors, exploiting the acidic, high-peroxide environment of cancer cells.
The dual-action approach, part of chemodynamic therapy, showed strong effectiveness in lab and mouse models, eliminating human breast tumors completely with no recurrence or toxicity.
The nanoagent outperformed previous treatments by producing both reactive oxygen species with higher efficiency.
The team plans to test it against other cancers, including pancreatic cancer.
The study, funded by the NIH, was published in Advanced Functional Materials.
Investigadores del estado de Oregon crearon un nanomaterial basado en hierro que mata el cáncer de mama en ratones usando especies de oxígeno reactivo dual, sin toxicidad o recurrencia.