Nancy Guthrie, 84, is missing in Tucson; authorities fear for her life due to medical needs and suspect she didn’t leave voluntarily.

Nancy Guthrie, 84, a Tucson, Arizona resident and mother of NBC’s Savannah Guthrie, is missing after being last seen Saturday night. Authorities declared her home a crime scene, citing evidence suggesting she did not leave voluntarily due to her physical limitations and urgent need for daily medication. A large-scale search involving federal and local agencies, including the FBI and Border Patrol canines, is underway using drones, surveillance tech, and forensic analysis. Officials stress the medical urgency—her condition could become life-threatening within 24 hours without medication—and urge the public to report any information, including photos or videos, through a dedicated hotline or anonymous tip line.