Patrick Mahomes’ ACL tear and underdog upsets led to the Chiefs and Eagles missing the Super Bowl, with the Seahawks advancing after signing Sam Darnold.

The 2025-2026 NFL season saw major upsets and injuries, with Patrick Mahomes sidelined by an ACL tear and the Seattle Seahawks reaching the Super Bowl after signing Sam Darnold. The New England Patriots ended the Bills’ AFC East streak, while the Bills lost in the Divisional Round despite a strong record. Injuries plagued teams like the 49ers and Ravens, and underdog teams like the Patriots and Seahawks outperformed expectations, leading to heavy betting payouts. The season’s unpredictability resulted in poor outcomes for favorites, with the Chiefs and Eagles failing to reach the Super Bowl, and bettors facing losses despite high wagering volume.