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LIR Life Sciences found a skin-applied semaglutide reduced blood sugar in mice as well as injections, a promising step for needle-free diabetes treatment.
LIR Life Sciences reported positive interim preclinical results showing a needle-free, topical semaglutide formulation using cell-penetrating peptides effectively lowered blood glucose in mice, matching injectable semaglutide in glucose tolerance tests.
The topical treatment reduced glucose spikes and accelerated return to baseline, indicating functional drug delivery through the skin.
These findings support the company’s transdermal platform for large peptide therapies, with potential applications in diabetes and obesity treatment.
The results are preliminary and not yet confirmed in humans.
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LIR Life Sciences descubrió que un semaglutido aplicado en la piel redujo el azúcar en la sangre en ratones, así como en inyecciones, un paso prometedor para el tratamiento de la diabetes sin agujas.