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Chronic stress from discrimination explains nearly half of the Black-White mortality gap in a St. Louis study.
A 2026 study in JAMA Network Open finds that nearly half of the racial mortality gap between Black and White Americans is linked to chronic stress and inflammation from lifelong exposure to discrimination.
Analyzing 17 years of data from over 1,500 St. Louis adults, researchers found Black participants had a 25% death rate versus 12% among White participants, with stress-related inflammation explaining 49.3% of the disparity.
Elevated biomarkers like C-reactive protein and interleukin-6—tied to long-term stress—were associated with earlier death, supporting the “weathering hypothesis.” While the study highlights systemic inequities as a root cause, more than half the gap remains unexplained, pointing to additional factors like healthcare access and environment.
El estrés crónico por discriminación explica casi la mitad de la brecha en la mortalidad entre negros y blancos en un estudio de St. Louis.