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Oregon State researchers created an iron-based nanomaterial that destroys breast cancer tumors in mice using targeted oxidative stress, with no toxicity and no recurrence.
Researchers at Oregon State University have developed an iron-based nanomaterial that kills cancer cells by generating two reactive oxygen species—hydroxyl radicals and singlet oxygen—specifically within tumors.
The nanoagent targets the acidic, high-hydrogen-peroxide environment of cancer cells, causing lethal oxidative stress while sparing healthy tissue.
In mouse models of human breast cancer, it led to complete tumor regression and long-term recurrence prevention with no systemic toxicity.
Unlike earlier treatments, this dual-action approach shows superior effectiveness.
The team, funded by federal health institutes, plans to test it against other cancers, including pancreatic cancer.
Human trials are still pending.
Los investigadores del estado de Oregon crearon un nanomaterial a base de hierro que destruye los tumores de cáncer de mama en ratones usando estrés oxidativo dirigido, sin toxicidad y sin recurrencia.