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A Yale study finds the nose's early interferon response, not the virus, determines cold severity.
A Yale-led study finds that the severity of a common cold is determined more by the body’s early immune response in the nasal lining than by the rhinovirus itself.
Using lab-grown nasal tissue, researchers discovered that a rapid interferon response can limit viral spread, keeping infections mild.
When this defense is weak or delayed, the virus infects more cells, triggering inflammation, mucus production, and severe symptoms.
The findings highlight the nose’s role as a frontline defense and suggest future treatments could target interferon pathways to prevent or ease colds, especially in people with asthma or COPD.
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Un estudio de Yale encuentra que la respuesta temprana de la nariz al interferón, no el virus, determina la severidad del resfriado.