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flag Opioid use disorders caused 75% of 78,000 drug-related deaths in the Americas in 2021, with rates rising sharply since 2000.

flag Drug use disorders are a rising public health crisis in the Americas, with 17.7 million people affected in 2021 and nearly 78,000 related deaths—four times the global average. flag Opioid use disorders caused over 75% of deaths, and the health burden nearly tripled since 2000. flag Young men are most affected, though deaths among women are increasing. flag Synthetic opioids drive harm in North America, while cannabis and cocaine are more prevalent in the Caribbean and Latin America. flag The pandemic worsened the crisis. flag PAHO urges expanded prevention, treatment, harm reduction, and integration of care into primary health systems, emphasizing medication-assisted treatment and early screening tools.

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