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A cholera toxin slowed tumor growth in mice by targeting cancer cells and boosting immunity without side effects, offering hope for safer cancer treatments.
A cholera-derived toxin called MakA slowed colorectal tumor growth in mice by targeting cancer cells and boosting immune activity without harming healthy tissue, according to a 2025 study from Umeå University.
The toxin accumulated in tumors, increased cancer cell death, and enhanced immune responses by raising levels of macrophages and neutrophils.
It triggered immune signals that kill cancer cells while avoiding harmful inflammation or organ damage.
No side effects were observed in mice, even with repeated doses.
Researchers say MakA shows promise as a targeted, less toxic cancer therapy, but further study is needed to assess its potential in humans.
Una toxina de cólera retrasó el crecimiento del tumor en ratones al atacar las células cancerosas y aumentar la inmunidad sin efectos secundarios, ofreciendo esperanzas de tratamientos más seguros contra el cáncer.