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flag A fruit fly study found 11 human genes affecting dopamine and sleep, including mask and clu, offering insights for treating Parkinson’s, depression, and sleep disorders.

flag A study using fruit flies has identified 11 human-relevant genes that regulate dopamine levels and sleep, with two—mask and clu—showing strong effects. flag Researchers screened genes linked to pigmentation, which shares pathways with dopamine, and found that silencing mask reduced dopamine and disrupted sleep patterns, reversible with L-DOPA, while clu increased sleep via a different mechanism. flag The findings may inform treatments for Parkinson’s, depression, and sleep disorders.

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