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Duke study shows healthy mitochondria transfer from glial cells to nerves reduces chronic pain in mice and human tissue, offering potential treatments for diabetic and chemo-induced nerve damage.
A Duke University study finds that restoring mitochondria to nerve cells via transfer from supporting glial cells reduces chronic nerve pain in mice and human tissue, offering potential treatments for diabetic neuropathy and chemotherapy-related nerve damage.
The process, dependent on tunneling nanotubes and the protein MYO10, improves energy flow and reduces inflammation, with pain relief lasting up to 48 hours.
Healthy mitochondria from donor cells were effective, but damaged ones were not.
The findings suggest that boosting this natural repair mechanism could lead to new therapies for nerve pain.
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El estudio de Duke muestra que la transferencia de mitocondrias sanas de las células gliales a los nervios reduce el dolor crónico en ratones y tejido humano, ofreciendo tratamientos potenciales para el daño nervioso inducido por diabetes y quimioterapia.