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CAR T-cell therapy shows promise in reversing age-related gut decline in mice and early human cells by clearing harmful senescent cells.
CAR T-cell therapy, originally for cancer, may help aging intestines heal by targeting harmful senescent cells that build up with age.
In mice, the treatment improved gut regeneration, reduced inflammation, boosted nutrient absorption, and protected against radiation damage, with effects lasting up to a year.
Early tests on human intestinal cells suggest similar benefits may be possible, offering potential for treating age-related gut decline and damage from cancer therapy.
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La terapia con células T CAR es prometedora para revertir el declive intestinal relacionado con la edad en ratones y células humanas tempranas al eliminar las células senescentes dañinas.