Trent Williams injured his hamstring on the first play, ending his season for the 49ers.

Starting left tackle Trent Williams was ruled out for the remainder of the San Francisco 49ers' game against the Chicago Bears after sustaining a right hamstring injury on the opening play. The injury occurred as Williams pursued an interception return for a touchdown, though he wasn't involved in the play itself. He did not return, and backup Austen Pleasants took over. Williams, a 12-time Pro Bowler and recent record-setter for most Pro Bowl selections by an offensive tackle, had started every game this season after missing seven in 2024 due to an ankle injury. His absence is a major blow to the 49ers’ offensive line.