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A bacterium from a frog's gut shrank and prevented colorectal tumors in mice, outperforming chemotherapy, but human trials are years away due to infection risks.
A bacterium, Ewingella americana, found in the Japanese tree frog’s gut, eliminated colorectal tumors in mice with a single dose and prevented recurrence, outperforming chemotherapy in tests.
It targets tumors directly and activates immune cells, thriving in low-oxygen environments where treatments often fail.
The bacteria cleared quickly from the bloodstream with no lasting toxicity, but researchers warn it may cause infections in humans, so human trials are years away.
The study, published in Gut Microbes, highlights the potential of microbial biodiversity in cancer therapy.
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Una bacteria del intestino de una rana redujo y evitó tumores colorrectales en ratones, superando la quimioterapia, pero los ensayos en humanos están a años de distancia debido a los riesgos de infección.