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flag AstraZeneca acquires global rights to Jacobio’s cancer drug JAB-23E73 in a $2B deal, with co-development in China.

flag Chinese biotech firm Jacobio Pharma has licensed its experimental pan-KRAS inhibitor JAB-23E73 to AstraZeneca in a deal worth up to $2 billion, including a $100 million upfront payment and potential milestone payments. flag AstraZeneca gains exclusive rights outside mainland China, while both companies will co-develop and market the drug in China. flag The Phase I drug targets KRAS mutations, common in pancreatic, colorectal, and lung cancers, affecting about 23% of all cancers. flag Jacobio selected AstraZeneca for its global reach and oncology expertise to advance combination therapies. flag Despite the deal’s significance, Jacobio’s shares dropped over 13% post-announcement, with some investors questioning the upfront cost, though the company defended the valuation as reasonable and emphasized long-term scientific goals.

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