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Shift work linked to aggressive breast cancer via disrupted sleep and LILRB4 overactivity, study finds.
A new study links disrupted sleep cycles from night and rotating shifts to more aggressive breast cancer, finding that circadian misalignment promotes tumor growth and spread in animal models.
Researchers identified an overactive immune checkpoint molecule, LILRB4, which suppresses the body’s ability to fight cancer.
Targeting LILRB4 reduced tumor progression even under disrupted conditions, suggesting a potential treatment.
The findings indicate that shift work may actively drive cancer development, not just increase risk, and underscore the need for protective strategies for the millions of Americans working irregular hours.
El trabajo por turnos está vinculado al cáncer de mama agresivo a través de la interrupción del sueño y la hiperactividad de LILRB4, según el estudio.