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flag The U.S. declared fentanyl a weapon of mass destruction due to its role in 57,000 overdose deaths in 2025.

flag The U.S. has classified fentanyl as a weapon of mass destruction, citing its role in about 57,000 overdose deaths in 2025. flag The designation, announced on December 22, 2025, treats illicit fentanyl networks as national security threats, enabling federal agencies to respond with expanded surveillance, sanctions, and potential military actions. flag The move reflects the drug’s extreme potency—just two milligrams can be lethal—and acknowledges its devastating impact on communities. flag While the decision frames the opioid crisis as a strategic threat, it has sparked debate over its legal and diplomatic implications, particularly regarding foreign involvement in fentanyl production.

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