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A new mRNA therapy temporarily rejuvenated aging mice's immune systems by stimulating liver cells to produce thymus-like signals.
A December 17, 2025, study in Nature reveals that a twice-weekly mRNA therapy using lipid nanoparticles can temporarily restore youthful immune function in aging mice by turning liver cells into factories for three key thymus-like signals.
The treatment boosted T-cell production and improved responses to vaccines and cancer immunotherapy, offering a safe, temporary approach to reversing age-related immune decline without long-term genetic changes.
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Una nueva terapia de ARNm rejuveneció temporalmente el sistema inmunológico de los ratones envejecidos al estimular las células del hígado para que produjeran señales similares a las del timo.