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flag Opioids caused 69% of drug deaths in Wales in 2024, with 288 fatalities, mostly from accidental overdoses involving multiple substances.

flag Opioids drove 69% of drug misuse deaths in Wales in 2024, with 288 fatalities—up from 377 total drug poisoning deaths the previous year—most involving heroin or morphine. flag Accidental overdoses accounted for 84% of cases, and 62% involved multiple substances, particularly opioids with cocaine or benzodiazepines. flag Death rates were more than five times higher in deprived areas, with men nearly three times more likely to die than women and 34% of victims over 50, including 17 under 25. flag The All-Wales Take-home Naloxone program prevented over 4,199 overdoses since 2013, with a 1.3% fatality rate in 307 incidents in 2024, and 2,476 new recipients last year.

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