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flag Older adults with both frailty and depression face over three times higher dementia risk, a study of 220,000 people finds.

flag A large international study finds that older adults with both physical frailty and depression face a significantly higher risk of dementia, with the combination accounting for about 17% of overall risk. flag Analyzing data from over 220,000 people across three major studies, researchers found that those with both conditions were more than three times as likely to develop dementia compared to those without either, while frailty alone increased risk by over 2.5 times and depression by 59%. flag The study highlights a strong interaction between the two factors, suggesting their combined effect may overwhelm the body’s resilience. flag Though the findings are observational and cannot prove causation, researchers say addressing both frailty and depression together could be a key strategy for reducing dementia risk.

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