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flag Spyre Therapeutics' lock-up period ends Dec. 13, 2025, lifting restrictions on share sales after a 60-day hold.

flag Certain shares of Spyre Therapeutics, including RSUs, Series A and B Preferred Stock, and common shares, are subject to a lock-up agreement ending December 13, 2025, following a 61-day restriction starting October 13, 2025. flag Executive officers and directors are barred from selling or transferring these shares, except under specific exceptions. flag The restriction lifts after the close of trading on the 60th day following the prospectus date, aiming to prevent market disruption and stabilize the stock price after the company’s public offering.

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