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Spain reports first non-travel-related mpox clade 1b case with human-to-human spread.
Spain has reported the first confirmed case of human-to-human transmission of the mpox clade 1b strain outside Africa, involving a 49-year-old Madrid man with no travel history to endemic regions.
He had received two doses of the Imvanex vaccine, presented with genital ulcers and swollen lymph nodes, and reported sexual contact with two local partners who also had no travel links to Africa.
PCR testing confirmed infection with clade 1b, marking the first instance of community spread without travel ties.
The strain, first identified in the DRC in 2023, is highly transmissible.
The WHO reported 2,501 new mpox cases and 12 deaths globally in October 2025.
Health officials are urging preventive measures, especially for high-risk groups, and promoting non-stigmatizing communication.
España reporta el primer caso de mpox clade 1b no relacionado con los viajes, con propagación de humano a humano.